Intended for Canadian Healthcare Professionals Only

Information for Patients:
About Collagenase SANTYL® Ointment
SANTYL Ointment
Welcome to This section provides information intended to help patients and caregivers learn more about SANTYL® Ointment.

What is SANTYL® Ointment?

Collagenase SANTYL® is an ointment used for certain kinds of skin ulcers, including chronic dermal ulcers (eg, pressure, diabetic, and venous stasis ulcers) or severely burned areas. These wounds often contain skin or other tissue that is no longer living, so it must be removed.

Sometimes the body can naturally shed this non-living tissue, as in the case of a scab. But in many skin ulcers, the tissue cannot be shed by the body, and that may result in delayed healing and/or infection. Collagenase SANTYL® Ointment contains an enzyme called collagenase, derived from a purified bacterial culture. This medicine helps break down the proteins in non-living tissue so that they can be removed from the wound. Removal of non-living tissue makes room for new, healthy cells to form, and helps the wound to heal or close.

Follow all your doctor’s instructions about using Collagenase SANTYL® Ointment. Generally, this medicine is applied once a day or more frequently if your dressing becomes soiled.

How to Use SANTYL® Ointment


Occasional slight transient erythema has been noted in surrounding tissue when applied outside the wound. One case of systemic hypersensitivity has been reported after 1 year of treatment with collagenase and cortisone.
Use of Collagenase SANTYL® Ointment should be terminated when debridement is complete and granulation tissue is well established.
See complete prescribing information for more details.



You are encouraged to report negative side effects of prescription drugs to Health Canada at 1-866-234-2345 or visit 

SANTYL® is a registered trademark of Healthpoint Biotherapeutics. Healthpoint Biotherapeutics and design is a registered trademark of Healthpoint Biotherapeutics.
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The information on this site is intended for customers, patients, and healthcare professionals in Canada only. All information, including the Prescribing Information for Collagenase SANTYL® Ointment, abides by the laws, regulatory requirements, and medical practices for Canada only and may not be appropriate for use outside of Canada.