Intended for Canadian Healthcare Professionals Only

Patient Frequently Asked Questions

Will there be any side effects?

Most people can use Collagenase SANTYL® Ointment without any complications, but, as with all medicines, it carries some risk of side effects. Although it does not harm healthy tissue, a small number of patients experience minor, temporary redness after using SANTYL® Ointment, especially if the ointment comes in contact with skin around the wound. Patients who have a lot of fluid and wound material buildup may notice irritation when they apply SANTYL® Ointment. If this happens, ask your healthcare provider if your wound dressing needs to be changed more often until the amount of buildup decreases. If you experience any other side effects, talk to your healthcare provider.

What is in SANTYL® Ointment?

The active ingredient in SANTYL® Ointment is an enzyme called collagenase. This is the active ingredient that helps break down one of the major proteins (collagen) that may keep non-living tissue connected to your body.

What if my wound gets infected?

You can still use SANTYL® Ointment if your wound becomes infected, but your doctor may instruct you to apply an antibiotic powder directly to the wound before using the ointment. He or she may ask you to stop using SANTYL® Ointment until the infection heals. Tell your doctor right away if you think your wound is infected.

Who should not use SANTYL® Ointment?

Anyone with an allergy, or with sensitivity to collagenase or any other ingredient in SANTYL® Ointment, should not use this product. You should not use SANTYL® Ointment unless it has been prescribed for you by a doctor.

How should I store SANTYL® Ointment?

SANTYL® Ointment should be stored at room temperature (not above 25°C or 77°F). As with all medications, keep out of the reach of children.

Where can I get more information?

Please read the SANTYL® Ointment product insert every time you refill your prescription. The information on this website is helpful and important, but it does not replace the product information or a discussion with your doctor. Ask your doctor or pharmacist if you have any other questions or concerns.


One last reminder: This medicine should be used only by the person for whom it was prescribed. Never share this medicine with another person, and use SANTYL® Ointment only for the condition for which it was prescribed and according to your doctor’s instructions.



Occasional slight transient erythema has been noted in surrounding tissue when applied outside the wound. One case of systemic hypersensitivity has been reported after 1 year of treatment with collagenase and cortisone.
Use of Collagenase SANTYL® Ointment should be terminated when debridement is complete and granulation tissue is well established.
See complete prescribing information for more details.



You are encouraged to report negative side effects of prescription drugs to Health Canada at 1-866-234-2345 or visit 

SANTYL® is a registered trademark of Healthpoint Biotherapeutics. Healthpoint Biotherapeutics and design is a registered trademark of Healthpoint Biotherapeutics.
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The information on this site is intended for customers, patients, and healthcare professionals in Canada only. All information, including the Prescribing Information for Collagenase SANTYL® Ointment, abides by the laws, regulatory requirements, and medical practices for Canada only and may not be appropriate for use outside of Canada.